Pleiotropic features of dihydropyridine calcium channel antagonists
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چکیده
منابع مشابه
PHARMAC responds to Stewart Mann on dihydropyridine calcium channel antagonists.
PHARMAC’s legislative objective is “to secure for eligible people in need of pharmaceuticals, the best health outcomes that are reasonably achievable from pharmaceutical treatment and from within the amount of funding provided.” Two of the ways in which PHARMAC achieves this is by reference pricing and by negotiating sole supply contracts with pharmaceutical suppliers. When managed appropriatel...
متن کاملDihydropyridine Calcium Channel Blockers
T he concept of proarrhythmia, the realization that antiarrhythmic drugs can occasionally drastically aggravate the very problem for which they were prescribed, is now widely appreciated and has undoubtedly lead to an overall improvement in the use of these drugs. Proarrhythmia is a particularly dangerous type of side effect: It is unpredictable, may easily escape detection, and can turn a beni...
متن کاملVoltage-dependent calcium channels--beyond dihydropyridine antagonists.
The blockade of L-type calcium channels by dihydropyridines, phenylalkylamines and benzothiazepines has been well described and forms the basis of a multibillion dollar market for the treatment of cardiovascular disease and migraine. More recently, neuron-specific calcium channels have become the subject of intense interest regarding their potential as therapeutic targets for the treatment of c...
متن کاملVoltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists.
We have investigated the mechanisms of blockade of calcium channel current by the dihydropyridines, e.g. nisoldipine, nitrendipine, and nicardipine. Membrane current was recorded in isolated calf Purkinje fibers using a two-microelectrode voltage-clamp technique, and voltage protocols were designed to identify voltage- and use-dependent block by these compounds systematically. Our results show ...
متن کاملA QUANTUM CHEMICAL STUDY OF STRUCTURE -ACTIVITY RELATIONSHIPS OF DIHYDROPYRIDINE CALCIUM ANTAGONISTS
Quantum chemical (MNDo)caleulations have beenused toelucidate the molecular properties and structure - activity relationships of dihydropyridine (DHP) type calcium antagonists. There is a good corielation between the net atomic charges on various atoms of the 4 - phenyl ring of dihydropyridines and pharmacological activity. .Also, activity decreases with increasing free rotation of the phen...
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ژورنال
عنوان ژورنال: Systemic Hypertension
سال: 2014
ISSN: 2542-2189,2075-082X
DOI: 10.26442/sg29053